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Article

New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.

European journal of oral sciences - 1 Jun 2011

Martinelli Marcella, Masiero Elena, Carinci Francesco, Morselli Paolo G, Pezzetti Furio, Scapoli Luca

Abstract excerpt

Orofacial clefts have a multifactorial aetiology encompassing both genetic and environmental components. While there is wide agreement on the importance of both genetic and nutritional factors, genetic influence in particular has not been well defined. As genetic variants in folate and homocysteine metabolism have been reported to influence the risk of orofacial clefts, an Italian cleft lip with or without cleft...

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Source

Identifiers

PMID: 21564312
DOI: 10.1111/j.1600-0722.2011.00824.x

Genes

CBS
BHMT
BHMT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.PMID 21564312Read ↗

Cystathionine beta-synthase c.844ins68 gene variant and non-syndromic cleft lip and palate.Semantic proximity Read ↗

Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway.Semantic proximity Read ↗

BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population.Semantic proximity Read ↗

Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations.Semantic proximity Read ↗

Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.Semantic proximity Read ↗

Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.Semantic proximity Read ↗

A family-based association study in Central Europeans: no evidence for the cystathionine beta-synthase c.844ins68 gene variant as a risk factor for non-syndromic cleft lip and palate.Semantic proximity Read ↗

Two SNPs rs1801133 and rs1801394 in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palateSemantic proximity Read ↗

Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.Semantic proximity Read ↗

Folate pathway and nonsyndromic cleft lip and palate.Semantic proximity Read ↗

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