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Article

Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific.

Breast cancer research : BCR - 17 Aug 2016

Chehade Rania, Pettapiece-Phillips Rachael, Salmena Leonardo, Kotlyar Max, Jurisica Igor, Narod Steven A, Akbari Mohammad R, Kotsopoulos Joanne

Abstract excerpt

BACKGROUND: BRCA1 mutation carriers face a high lifetime risk of developing both breast and ovarian cancer. Haploinsufficiency is thought to predispose these women to cancer by reducing the pool of available BRCA1 transcript and protein, thereby compromising BRCA1 function. Whether or not cancer-free BRCA1 mutation carriers have lower messenger (m)RNA transcript levels in peripheral blood leukocytes has not been...

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Identifiers

PMID: 27534398
DOI: 10.1186/s13058-016-0739-8
PMCID: PMC4989508

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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