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Article

Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer.

Experimental and molecular pathology - 1 Apr 2023

Jasiak Anna, Koczkowska Magdalena, Stukan Maciej, Wydra Dariusz, Biernat Wojciech, Izycka-Swieszewska Ewa, Buczkowski Kamil, Eccles Michael R, Walker Logan, Wasag Bartosz, Ratajska Magdalena

Abstract excerpt

BACKGROUND: The mRNA splicing is regulated on multiple levels, resulting in the proper distribution of genes' transcripts in each cell and maintaining cell homeostasis. At the same time, the expression of alternative transcripts can change in response to underlying genetic variants, often missed during routine diagnostics. AIM: The main aim of this study was to define the frequency of aberrant splicing in BRCA1...

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Source

Identifiers

PMID: 36791903
DOI: 10.1016/j.yexmp.2023.104856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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