Article
DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers.
Breast cancer research and treatment - 1 Jul 2015
Vaclová Tereza, Gómez-López Gonzalo, Setién Fernando, Bueno José María García, Macías José Antonio, Barroso Alicia, Urioste Miguel, Esteller Manel, Benítez Javier, Osorio Ana
Abstract excerpt
BRCA1 germline mutations increase the lifetime risk of developing breast and ovarian cancers. However, taking into account the differences in disease manifestation among mutation carriers, it is probable that different BRCA1 mutations have distinct haploinsufficiency effects and lead to the formation of different phenotypes. Using lymphoblastoid cell lines derived from heterozygous BRCA1 mutation carriers and...
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