Article
Allelic transcripts dosage effect in morphologically normal ovarian cells from heterozygous carriers of a BRCA1/2 French Canadian founder mutation.
Cancer prevention research (Philadelphia, Pa.) - 1 May 2012
Abd-Rabbo Diala, Abaji Christine, Cardin Guillaume B, Filali-Mouhim Abdelali, Arous Caroline, Portelance Lise, Escobar Enrique, Cloutier Sophie, Tonin Patricia N, Provencher Diane M, Mes-Masson Anne-Marie, Maugard Christine M
Abstract excerpt
We hypothesized that the transcriptome of primary cultures of morphologically normal ovarian surface epithelial cells could be altered by the presence of a heterozygous BRCA1 or BRCA2 mutation. We aimed to discover early events associated with ovarian carcinogenesis, which could represent putative targets for preventive strategies of this silent killer tumor. We identified the first molecular signature associated...
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