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Article

Genome instability in blood cells of a BRCA1+ breast cancer family.

BMC cancer - 19 May 2014

Xiao Fengxia, Kim Yeong C, Snyder Carrie, Wen Hongxiu, Chen Pei Xian, Luo Jiangtao, Becirovic Dina, Downs Bradley, Cowan Kenneth H, Lynch Henry, Wang San Ming

Abstract excerpt

BACKGROUND: BRCA1 plays an essential role in maintaining genome stability. Inherited BRCA1 germline mutation (BRCA1+) is a determined genetic predisposition leading to high risk of breast cancer. While BRCA1+ induces breast cancer by causing genome instability, most of the knowledge is known about somatic genome instability in breast cancer cells but not germline genome instability. METHODS: Using the...

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Source

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Identifiers

PMID: 24884718
DOI: 10.1186/1471-2407-14-342
PMCID: PMC4031489

Genes

BRCA1
BPTF
FOXP1
PHKG2
SRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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