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Article

Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients.

PLoS genetics - 19 Feb 2010

Walker Logan C, Thompson Bryony A, Waddell Nic, Grimmond Sean M, Spurdle Amanda B

Abstract excerpt

A large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2. Laboratory-based methods that can distinguish between carriers of pathogenic mutations and non-carriers are likely to have utility for the cla...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20174566
DOI: 10.1371/journal.pgen.1000850
PMCID: PMC2824809

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20174566-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients.PMID 20174566Read ↗

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Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific.Semantic proximity Read ↗

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Gene expression profiling after radiation-induced DNA damage is strongly predictive of BRCA1 mutation carrier status.Semantic proximity Read ↗

Gene-expression profiles in hereditary breast cancer.Semantic proximity Read ↗

Molecular classification of familial non-BRCA1/BRCA2 breast cancer.Semantic proximity Read ↗

Accurate prediction of BRCA1 and BRCA2 heterozygous genotype using expression profiling after induced DNA damage.Semantic proximity Read ↗

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