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Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency.

Genes, chromosomes & cancer - 1 Jan 2010

Rennstam Karin, Ringberg Anita, Cunliffe Heather E, Olsson Håkan, Landberg Göran, Hedenfalk Ingrid

Abstract excerpt

Multiple biopsies of normal breast tissue from 10 BRCA1 mutation carriers have been analyzed using array-based comparative genomic hybridization. Normal breast tissue from five age-matched control subjects without a family history of breast cancer was included for reference purposes. We repeatedly found multiple low copy number aberrations at a significantly higher frequency in histopathologically normal tissue...

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Identifiers

PMID: 19839046
DOI: 10.1002/gcc.20723

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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