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Article

Structure of a human pre-40S particle points to a role for RACK1 in the final steps of 18S rRNA processing

16 Aug 2016

Abstract excerpt

Synthesis of ribosomal subunits in eukaryotes is a complex and tightly regulated process that has been mostly characterized in yeast. The discovery of a growing number of diseases linked to defects in ribosome biogenesis calls for a deeper understanding of these mechanisms and of the specificities of human ribosome maturation. We present the 19 Å resolution cryo-EM reconstruction of a cytoplasmic precursor to the...

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PMID: 27530427
DOI: 10.1093/nar/gkw714

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