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Article

Structure of the large ribosomal subunit from human mitochondria.

Science (New York, N.Y.) - 7 Nov 2014

Brown Alan, Amunts Alexey, Bai Xiao-Chen, Sugimoto Yoichiro, Edwards Patricia C, Murshudov Garib, Scheres Sjors H W, Ramakrishnan V

Abstract excerpt

Human mitochondrial ribosomes are highly divergent from all other known ribosomes and are specialized to exclusively translate membrane proteins. They are linked with hereditary mitochondrial diseases and are often the unintended targets of various clinically useful antibiotics. Using single-particle cryogenic electron microscopy, we have determined the structure of its large subunit to 3.4 angstrom resolution,...

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Identifiers

PMID: 25278503
DOI: 10.1126/science.1258026
PMCID: PMC4246062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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