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Article

60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes.

Nucleic acids research - 1 Sept 2008

Lebreton Alice, Rousselle Jean-Claude, Lenormand Pascal, Namane Abdelkader, Jacquier Alain, Fromont-Racine Micheline, Saveanu Cosmin

Abstract excerpt

During the highly conserved process of eukaryotic ribosome formation, RNA follows a maturation path with well-defined, successive intermediates that dynamically associate with many pre-ribosomal proteins. A comprehensive description of the assembly process is still lacking. To obtain data on the timing and order of association of the different pre-ribosomal factors, a strategy consists in the use of pre-ribsomal...

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PMID: 18658244
DOI: 10.1093/nar/gkn469
PMCID: PMC2528192

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