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Article

Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.

The Journal of cell biology - 6 Sept 2010

O'Donohue Marie-Françoise, Choesmel Valérie, Faubladier Marlène, Fichant Gwennaële, Gleizes Pierre-Emmanuel

Abstract excerpt

Our knowledge of the functions of metazoan ribosomal proteins in ribosome synthesis remains fragmentary. Using siRNAs, we show that knockdown of 31 of the 32 ribosomal proteins of the human 40S subunit (ribosomal protein of the small subunit [RPS]) strongly affects pre-ribosomal RNA (rRNA) processing, which often correlates with nucleolar chromatin disorganization. 16 RPSs are strictly required for initiating...

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Identifiers

PMID: 20819938
DOI: 10.1083/jcb.201005117
PMCID: PMC2935573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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