Article
Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes.
Nucleic acids research - 1 Jul 2014
Ferreira-Cerca Sébastien, Kiburu Irene, Thomson Emma, LaRonde Nicole, Hurt Ed
Abstract excerpt
During eukaryotic ribosome biogenesis, members of the conserved atypical serine/threonine protein kinase family, the RIO kinases (Rio1, Rio2 and Rio3) function in small ribosomal subunit biogenesis. Structural analysis of Rio2 indicated a role as a conformation-sensing ATPase rather than a kinase to regulate its dynamic association with the pre-40S subunit. However, it remained elusive at which step and by which...
Topics
- Adenosine Triphosphatases
- Aspartic Acid
- Catalytic Domain
- Humans
- Models, Molecular
- Mutation
- Protein Serine-Threonine Kinases
- Ribosome Subunits, Large, Eukaryotic
- Ribosome Subunits, Small, Eukaryotic
- Ribosomes