Article
RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.
PLoS genetics - 1 Jun 2021
Cerezo Emilie L, Houles Thibault, Lié Oriane, Sarthou Marie-Kerguelen, Audoynaud Charlotte, Lavoie Geneviève, Halladjian Maral, Cantaloube Sylvain, Froment Carine, Burlet-Schiltz Odile, Henry Yves, Roux Philippe P, Henras Anthony K, Romeo Yves
Abstract excerpt
Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is regulated by well-described transcriptional mechanisms, but a growing body of evidence indicates that other levels of regulation exist. Here we show that the Ras/mitogen-activated protein kinase (MAPK) pathway stimulates post-transcriptional stages of human...
Topics
- HEK293 Cells
- Humans
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Protein Transport
- Ribosome Subunits, Small
- Signal Transduction