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Article

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.

PLoS genetics - 1 Jun 2021

Cerezo Emilie L, Houles Thibault, Lié Oriane, Sarthou Marie-Kerguelen, Audoynaud Charlotte, Lavoie Geneviève, Halladjian Maral, Cantaloube Sylvain, Froment Carine, Burlet-Schiltz Odile, Henry Yves, Roux Philippe P, Henras Anthony K, Romeo Yves

Abstract excerpt

Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is regulated by well-described transcriptional mechanisms, but a growing body of evidence indicates that other levels of regulation exist. Here we show that the Ras/mitogen-activated protein kinase (MAPK) pathway stimulates post-transcriptional stages of human...

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Identifiers

PMID: 34125833
DOI: 10.1371/journal.pgen.1009583
PMCID: PMC8224940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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