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Article

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function

15 Aug 2016

Abstract excerpt

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warranted. Activin...

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PMID: 27528762
DOI: 10.1042/bst20160093

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