Molecular Pathways: Can Activin-like Kinase Pathway Inhibition Enhance the Limited Efficacy of VEGF Inhibitors?

Abstract excerpt

The vascular endothelial growth factor (VEGF) pathway is critical for tumor angiogenesis. However, VEGF pathway inhibition has been limited by intrinsic and acquired resistance. Simultaneously targeting multiple steps involved in tumor angiogenesis is a potential means of overcoming this resistance. Activin like kinase 1 (ALK1) and endoglin (ENG) have effects on angiogenesis that are distinct from those of VEGF....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connective Tissue Growth Factor Research
• Share to TGF-β signaling in diseases
• Share to Vascular Anomalies and Treatments