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Regulation of the ALK1 ligands, BMP9 and BMP10

15 Aug 2016

Abstract excerpt

Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1), a type I BMP receptor mainly expressed on vascular endothelial cells (ECs). ALK1-mediated BMP9/BMP10 signalling pathways have emerged as essential in EC biology and in angiogenesis. Several genetic mutations in the genes encoding the ligands and receptors of this pathway have been reported in two...

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PMID: 27528761
DOI: 10.1042/bst20160083

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