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Article

Activin receptor–like kinase 1 is implicated in the maturation phase of angiogenesis

26 Nov 2002

Abstract excerpt

Activin receptor-like kinase 1 (ALK-1) is an orphan type I receptor of the transforming growth factor beta (TGF-beta) receptor family. In vivo studies have demonstrated that this endothelial-specific receptor is implicated in angiogenesis. In this study, we addressed the cellular function of ALK-1 in cultured human microvascular endothelial cells from the dermis (HMVEC-d's) using adenoviral expression of a...

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PMID: 12453878
DOI: 10.1182/blood.v100.13.4495

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