Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?

doi:10.1007/s00018-013-1331-3

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Article

Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?

Cellular and molecular life sciences : CMLS - 1 Nov 2013

Bottos Alessia, Bardelli Alberto

Abstract excerpt

The acquisition of oncogenic mutations and promotion of angiogenesis are key hallmarks of cancer. These features are often thought of as separate events in tumor progression and the two fields of research have frequently been considered as independent. However, as we highlight in this review, activated oncogenes and deregulated angiogenesis are tightly associated, as mutations in cancer cells can lead to...

Topics

Angiogenesis Inhibitors
Animals
Antineoplastic Agents
Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Mutation
Neoplasms
Neovascularization, Pathologic
Oncogenes
Precision Medicine

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Identifiers

PMID: 23685900
DOI: 10.1007/s00018-013-1331-3
PMCID: PMC11113350

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