Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

11 Jan 2010

Abstract excerpt

Members of the transforming growth factor beta (TGF-beta) family have been genetically linked to vascular formation during embryogenesis. However, contradictory studies about the role of TGF-beta and other family members with reported vascular functions, such as bone morphogenetic protein (BMP) 9, in physiological and pathological angiogenesis make the need for mechanistic studies apparent. We demonstrate, by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterotopic Ossification and Related Conditions
Share to Kruppel-like factors research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20065063
DOI: 10.1084/jem.20091309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesisPMID 20065063Read ↗

ALK1 as an emerging target for antiangiogenic therapy of cancerSemantic proximity Read ↗

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 functionSemantic proximity Read ↗

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.Semantic proximity Read ↗

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapySemantic proximity Read ↗

Regulation of the ALK1 ligands, BMP9 and BMP10Semantic proximity Read ↗

Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways.Semantic proximity Read ↗

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approachSemantic proximity Read ↗

Molecular Pathways: Can Activin-like Kinase Pathway Inhibition Enhance the Limited Efficacy of VEGF Inhibitors?Semantic proximity Read ↗

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation.Semantic proximity Read ↗

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling ComplexSemantic proximity Read ↗

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasiaSemantic proximity Read ↗

BMP9 and BMP10 : Two close vascular quiescence partners that stand outSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.