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Article

ALK1 as an emerging target for antiangiogenic therapy of cancer

6 Apr 2011

Abstract excerpt

Members of the TGF-β family act on many, if not all, cell types within the body, producing diverse and complex cellular outcomes. Activation of the endothelial cell-restricted TGF-β type I receptor ALK1 results from the binding of several different ligands of the TGF-β family, including bone morphogenetic protein (BMP) 9, BMP10, and TGF-β. Mounting genetic, pharmacologic, and histopathologic evidence supports a...

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PMID: 21467543
DOI: 10.1182/blood-2011-01-330142

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