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Article

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy

21 Sept 2013

Abstract excerpt

INTRODUCTION: Formation of blood vessels from pre-existing ones, also termed angiogenesis, is of crucial importance for the outgrowth of tumours beyond 1 - 2 mm³. Therefore, anti-angiogenic therapies, mainly focussing on inhibition of vascular endothelial growth factor (VEGF) are used in clinical therapy. However, although initially reducing tumour size, therapy resistance occurs frequently and new targets are...

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PMID: 24053899
DOI: 10.1517/13543784.2013.837884

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