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Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition

15 Aug 2016

Abstract excerpt

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent...

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PMID: 27528760
DOI: 10.1042/bst20160069

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