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Article

Bi‐directional roles of bone morphogenetic proteins in cancer: Another molecular Jekyll and Hyde?

1 Jun 2013

Abstract excerpt

Bone morphogenetic proteins (BMPs) are multi-functional cytokines, which belong to the transforming growth factor-β (TGF-β) family. In some cancer tissues, aberrant expression of various BMP signal components has been detected. Here, we describe the divergent roles of BMPs during the progression of cancer. BMPs exhibit various effects on both cancer cells and on tumor microenvironments. BMPs inhibit the...

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PMID: 23782330
DOI: 10.1111/pin.12067

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