Article

MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia

2026-01-08

Abstract excerpt

Mutations in SET binding protein 1 ( SETBP1 ) are associated with an adverse prognosis in myeloid malignancies. These mutations stabilize SETBP1 protein, driving increased expression of a progenitor-associated gene expression program through incompletely described mechanisms. A proteomic screen revealed interactions between SETBP1 and members of the MYST acetyltransferase complexes, including the catalytic subuni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a046f1a9-9cba-585b-8f58-6cc697750e19
DOI: 10.64898/2026.01.08.697228

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemiaDOI 10.64898/2026.01.08.697228Read

MYST Acetyltransferases Interact with SETBP1 and Are a Targetable Therapeutic Vulnerability in SETBP1-Mutant Leukemia.Semantic proximity Read

KATs in the MYST: A New Therapeutic Vulnerability for SETBP1-Mutated Myeloid Malignancies.Semantic proximity Read

Mutant- <i>SETBP1</i> activates transcription of Myc programs to accelerate <i>CSF3R</i> -driven myeloproliferative neoplasmsSemantic proximity Read

KAT7 is a therapeutic vulnerability of <i>MLL</i> -rearranged acute myeloid leukemiaSemantic proximity Read

SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.Semantic proximity Read

SETBP1 is dispensable for normal and malignant hematopoiesis.Semantic proximity Read

Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemiaSemantic proximity Read

SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML.Semantic proximity Read

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia.Semantic proximity Read

Myb expression is critical for myeloid leukemia development induced by Setbp1 activationSemantic proximity Read

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.Semantic proximity Read

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformationSemantic proximity Read