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Article

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites.

British journal of clinical pharmacology - 1 Aug 2007

Turpeinen Miia, Koivuviita Niina, Tolonen Ari, Reponen Petri, Lundgren Stefan, Miettunen Jouko, Metsärinne Kaj, Rane Anders, Pelkonen Olavi, Laine Kari

Abstract excerpt

AIMS: To investigate the effect of kidney disease on bupropion pharmacokinetics and on cytochrome P450 (CYP) 2B6 activity as measured by bupropion hydroxylation. METHODS: In an open parallel group study, 17 healthy, nonsmoking subjects and 10 patients with impaired kidney function received a single 150 mg oral dose of sustained release bupropion. Plasma concentrations of bupropion and its metabolites were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17335546
DOI: 10.1111/j.1365-2125.2007.02866.x
PMCID: PMC2000634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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