Article
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.
Nature - 8 Sept 2016
Kotzin Jonathan J, Spencer Sean P, McCright Sam J, Kumar Dinesh B Uthaya, Collet Magalie A, Mowel Walter K, Elliott Ellen N, Uyar Asli, Makiya Michelle A, Dunagin Margaret C, Harman Christian C D, Virtue Anthony T, Zhu Stella, Bailis Will, Stein Judith, Hughes Cynthia, Raj Arjun, Wherry E John, Goff Loyal A, Klion Amy D, Rinn John L, Williams Adam, Flavell Richard A, Henao-Mejia Jorge
Abstract excerpt
Neutrophils, eosinophils and 'classical' monocytes collectively account for about 70% of human blood leukocytes and are among the shortest-lived cells in the body. Precise regulation of the lifespan of these myeloid cells is critical to maintain protective immune responses and minimize the deleterious consequences of prolonged inflammation. However, how the lifespan of these cells is strictly controlled remains...
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