Article
Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
Cell reports - 23 Jun 2020
Cai Zhigang, Aguilera Fabiola, Ramdas Baskar, Daulatabad Swapna Vidhur, Srivastava Rajneesh, Kotzin Jonathan J, Carroll Martin, Wertheim Gerald, Williams Adam, Janga Sarath Chandra, Zhang Chi, Henao-Mejia Jorge, Kapur Reuben
Abstract excerpt
Inhibition of anti-apoptotic proteins BCL-2 and MCL-1 to release pro-apoptotic protein BIM and reactivate cell death could potentially be an efficient strategy for the treatment of leukemia. Here, we show that a lncRNA, MORRBID, a selective transcriptional repressor of BIM, is overexpressed in human acute myeloid leukemia (AML), which is associated with poor overall survival. In both human and animal models,...
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