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Article

RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening

20 Aug 2024

Abstract excerpt

Telomere shortening is a prominent hallmark of aging and is emerging as a characteristic feature of Myelodysplastic Syndromes (MDS) and Idiopathic Pulmonary Fibrosis (IPF). Optimal telomerase activity prevents progressive shortening of telomeres that triggers DNA damage responses. However, the upstream regulation of telomerase holoenzyme components remains poorly defined. Here, we identify RIOK2, a master...

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Share to Advanced biosensing and bioanalysis techniques
Share to Chromosomal and Genetic Variations
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39164231
DOI: 10.1038/s41467-024-51336-3

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