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TNF is a homoeostatic regulator of distinct epigenetically primed human osteoclast precursors

10 Mar 2021

Abstract excerpt

Objectives Circulating myeloid precursors are responsible for post-natal osteoclast (OC) differentiation and skeletal health, although the exact human precursors have not been defined. Enhanced osteoclastogenesis contributes to joint destruction in rheumatoid arthritis (RA) and tumour necrosis factor (TNF) is a well-known pro-osteoclastogenic factor. Herein, we investigated the interplay between receptor...

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PMID: 33692019
DOI: 10.1136/annrheumdis-2020-219262

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