Article
Review of Critical Issues in the Pathogenesis of Atopic Dermatitis.
Seminars in cutaneous medicine and surgery - 1 Jun 2016
Irvine Alan D, Eichenfield Lawrence F, Friedlander Sheila F, Simpson Eric L
Abstract excerpt
About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion...
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