Article
Identification of human ELOVL5 enhancer regions controlled by SREBP.
Biochemical and biophysical research communications - 2 Oct 2015
Shikama Akito, Shinozaki Haruna, Takeuchi Yoshinori, Matsuzaka Takashi, Aita Yuichi, Murayama Tomoki, Sawada Yoshikazu, Piao Xiaoying, Toya Naoki, Oya Yukari, Takarada Ayako, Masuda Yukari, Nishi Makiko, Kubota Midori, Izumida Yoshihiko, Nakagawa Yoshimi, Iwasaki Hitoshi, Kobayashi Kazuto, Yatoh Shigeru, Suzuki Hiroaki, Yagyu Hiroaki, Kawakami Yasushi, Yamada Nobuhiro, Shimano Hitoshi, Yahagi Naoya
Abstract excerpt
Fatty acid elongase 5 (ELOVL5) is an enzyme involved in the synthesis of polyunsaturated fatty acids. Sterol Regulatory Element-binding Protein (SREBP)-1 activates ELOVL5 and increases polyunsaturated fatty acid synthesis, which in turn negatively affects SREBP-1 expression. Thus, ELOVL5 has been established as an SREBP-1 target gene and an important component of the negative feedback loop of de novo lipogenesis....
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