Article

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation

2020-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for use in both lipid catabolism and lipid synthesis, including of arachidonic acid mediators that promote inflammation. ACSL1 has also been linked to the pro-atherosclerotic effects of diabetes in mice. ACSL1 expression has been reported to be upregulated in monocytes and macrophages by hyperglycemia, a...

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Literature Corpus work: fb5baf69-dc03-5bf4-a59b-4ec4df6dcc62
DOI: 10.1101/2020.08.04.235887

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