Effect of childhood general traumas on suicide attempt depends on TPH2 and ADARB1 variants in psychiatric patients.

doi:10.1007/s00702-017-1677-z

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Article

Effect of childhood general traumas on suicide attempt depends on TPH2 and ADARB1 variants in psychiatric patients.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2017

Karanović Jelena, Ivković Maja, Jovanović Vladimir M, Šviković Saša, Pantović-Stefanović Maja, Brkušanin Miloš, Damjanović Aleksandar, Brajušković Goran, Savić-Pavićević Dušanka

Abstract excerpt

Suicidal behavior has been associated with a deficient serotonin neurotransmission which is likely a consequence of individual genetic architecture, exposure to environmental factors and interactions of those factors. We examined whether the interaction of child abuse, TPH2 (tryptophan hydroxylase 2) variant rs4290270, affecting alternative splicing and editing of TPH2 pre-mRNAs, and ADARB1 (adenosine deaminase...

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PMID: 28084537
DOI: 10.1007/s00702-017-1677-z

Genes

TPH2
ADARB1

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