Article
Genetic determinants of major blood lipids in Pakistanis compared with Europeans.
Circulation. Cardiovascular genetics - 1 Aug 2010
Saleheen Danish, Soranzo Nicole, Rasheed Asif, Scharnagl Hubert, Gwilliam Rhian, Alexander Myriam, Inouye Michael, Zaidi Moazzam, Potter Simon, Haycock Philip, Bumpstead Suzanna, Kaptoge Stephen, Di Angelantonio Emanuele, Sarwar Nadeem, Hunt Sarah E, Sheikh Nasir, Shah Nabi, Samuel Maria, Haider Shajjia Razi, Murtaza Muhammed, Thompson Alexander, Gobin Reeta, Butterworth Adam, Ahmad Usman, Hakeem Abdul, Zaman Khan Shah, Kundi Assadullah, Yaqoob Zia, Cheema Liaquat Ali, Qamar Nadeem, Faruqui Azhar, Mallick Nadeem Hayat, Azhar Muhammad, Samad Abdus, Ishaq Muhammad, Rasheed Syed Zahed, Jooma Rashid, Niazi Jawaid Hassan, Gardezi Ali Raza, Memon Nazir Ahmed, Ghaffar Abdul, Rehman Fazal-ur, Hoffmann Michael Marcus, Renner Wilfried, Kleber Marcus E, Grammer Tanja B, Stephens Jonathon, Attwood Anthony, Koch Kerstin, Hussain Mustafa, Kumar Kishore, Saleem Asim, Kumar Kishwar, Daood Muhammad Salman, Gul Aftab Alam, Abbas Shahid, Zafar Junaid, Shahid Faisal, Bhatti Shahzad Majeed, Ali Syed Saadat, Muhammad Fahim, Sagoo Gurdeep, Bray Sarah, McGinnis Ralph, Dudbridge Frank, Winkelmann Bernhard R, Böehm Bernhard, Thompson Simon, Ouwehand Willem, März Winfried, Frossard Philippe, Danesh John, Deloukas Panos
Abstract excerpt
BACKGROUND: Evidence is sparse about the genetic determinants of major lipids in Pakistanis. METHODS AND RESULTS: Variants (n=45 000) across 2000 genes were assessed in 3200 Pakistanis and compared with 2450 Germans using the same gene array and similar lipid assays. We also did a meta-analysis of selected lipid-related variants in Europeans. Pakistani genetic architecture was distinct from that of several ethnic...
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