Article
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Nature communications - 22 Dec 2015
Tang Clara S, Zhang He, Cheung Chloe Y Y, Xu Ming, Ho Jenny C Y, Zhou Wei, Cherny Stacey S, Zhang Yan, Holmen Oddgeir, Au Ka-Wing, Yu Haiyi, Xu Lin, Jia Jia, Porsch Robert M, Sun Lijie, Xu Weixian, Zheng Huiping, Wong Lai-Yung, Mu Yiming, Dou Jingtao, Fong Carol H Y, Wang Shuyu, Hong Xueyu, Dong Liguang, Liao Yanhua, Wang Jiansong, Lam Levina S M, Su Xi, Yan Hua, Yang Min-Lee, Chen Jin, Siu Chung-Wah, Xie Gaoqiang, Woo Yu-Cho, Wu Yangfeng, Tan Kathryn C B, Hveem Kristian, Cheung Bernard M Y, Zöllner Sebastian, Xu Aimin, Eugene Chen Y, Jiang Chao Qiang, Zhang Youyi, Lam Tai-Hing, Ganesh Santhi K, Huo Yong, Sham Pak C, Lam Karen S L, Willer Cristen J, Tse Hung-Fat, Gao Wei
Abstract excerpt
Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 × 10(-7)),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.