Article
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
Nature genetics - 1 Dec 2017
Lu Xiangfeng, Peloso Gina M, Liu Dajiang J, Wu Ying, Zhang He, Zhou Wei, Li Jun, Tang Clara Sze-Man, Dorajoo Rajkumar, Li Huaixing, Long Jirong, Guo Xiuqing, Xu Ming, Spracklen Cassandra N, Chen Yang, Liu Xuezhen, Zhang Yan, Khor Chiea Chuen, Liu Jianjun, Sun Liang, Wang Laiyuan, Gao Yu-Tang, Hu Yao, Yu Kuai, Wang Yiqin, Cheung Chloe Yu Yan, Wang Feijie, Huang Jianfeng, Fan Qiao, Cai Qiuyin, Chen Shufeng, Shi Jinxiu, Yang Xueli, Zhao Wanting, Sheu Wayne H-H, Cherny Stacey Shawn, He Meian, Feranil Alan B, Adair Linda S, Gordon-Larsen Penny, Du Shufa, Varma Rohit, Chen Yii-Der Ida, Shu Xiao-Ou, Lam Karen Siu Ling, Wong Tien Yin, Ganesh Santhi K, Mo Zengnan, Hveem Kristian, Fritsche Lars G, Nielsen Jonas Bille, Tse Hung-Fat, Huo Yong, Cheng Ching-Yu, Chen Y Eugene, Zheng Wei, Tai E Shyong, Gao Wei, Lin Xu, Huang Wei, Abecasis Goncalo, Kathiresan Sekar, Mohlke Karen L, Wu Tangchun, Sham Pak Chung, Gu Dongfeng, Willer Cristen J
Abstract excerpt
Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants...
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