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Article

Effect of the interleukin-6 promoter polymorphism (−174 G/C) on the incidence and outcome of sepsis

1 Jan 2002

Abstract excerpt

OBJECTIVE: A biallelic polymorphism within the human interleukin (IL)-6 gene promoter region (-174 G/C) has been shown to affect IL-6 transcription in vitro and IL-6 plasma levels in healthy adults. Because IL-6 is excessively released into the circulation during sepsis and closely correlates with the clinical course, we studied whether this promoter polymorphism has an effect on the incidence and/or outcome of...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 11902285
DOI: 10.1097/00003246-200201000-00005

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