Article
Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.
Shock (Augusta, Ga.) - 1 Nov 2012
Sponholz Christoph, Huse Klaus, Kramer Marcel, Giamarellos-Bourboulis Evangelos J, Claus Ralf A, Kern Anna, Engel Christoph, Kuhnt Evelyn, Kiehntopf Michael, Routsi Christina, Mylona Vassiliki, Tsangaris Iraklis, Heinemann Stefan H, Reinhart Konrad, Platzer Matthias, Bauer Michael
Abstract excerpt
Heme and its breakdown products CO, Fe, and bilirubin are being recognized as signaling molecules or even therapeutic agents, but also exert adverse effects when released at high concentrations. Manipulating the pathway confers protection in rodent sepsis models via both control of free heme and formation of its first and higher-order products. Thus, regulatory elements present in human heme oxygenase 1 (HMOX1)...
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