Article
Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.
Respiratory research - 6 Jul 2023
Gao Li, Rafaels Nicholas, Dudenkov Tanda M, Damarla Mahendra, Damico Rachel, Maloney James P, Moss Marc, Martin Greg S, Sevransky Jonathan, Shanholtz Carl, Herr Dan L, Garcia Joe G N, Hernandez-Beeftink Tamara, Villar Jesús, Flores Carlos, Beaty Terri H, Brower Roy, Hassoun Paul M, Barnes Kathleen C
Abstract excerpt
BACKGROUND: Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders including sepsis and sepsis-associated acute respiratory distress syndrome (ARDS). We examined whether single nucleotide polymorphisms (SNPs) in the XDH gene (encoding...
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