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Article

Association of BRCA1 Mutations with Impaired Ovarian Reserve: Connection Between Infertility and Breast/Ovarian Cancer Risk.

Journal of adolescent and young adult oncology - 1 Dec 2016

Giordano Sara, Garrett-Mayer Elizabeth, Mittal Navdha, Smith Kristin, Shulman Lee, Passaglia Carolyn, Gradishar William, Pavone Mary Ellen

Abstract excerpt

PURPOSE: Mutations in the BRCA1/2 genes are associated with breast and ovarian cancer susceptibility. Recent studies have suggested that the BRCA mutation might be associated with occult primary ovarian insufficiency. To evaluate fertility, several studies have validated anti-Mullerian hormone (AMH) as a direct biomarker for ovarian aging and it is considered a quantitative marker of ovarian reserve. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27513691
DOI: 10.1089/jayao.2016.0009
PMCID: PMC5144867

Genes

AMH
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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