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Article

Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis.

Breast (Edinburgh, Scotland) - 1 Dec 2021

Gasparri Maria Luisa, Di Micco Rosa, Zuber Veronica, Taghavi Katayoun, Bianchini Giampaolo, Bellaminutti Serena, Meani Francesco, Graffeo Rossella, Candiani Massimo, Mueller Michael D, Papadia Andrea, Gentilini Oreste D

Abstract excerpt

INTRODUCTION: Preliminary clinical evidence suggests a detrimental effect of pathogenic variants of BRCA1 and 2 genes on fertility outcome. This meta-analysis evaluates whether women carrying BRCA mutations (BRCAm) have decreased ovarian reserve, in terms of Anti-Muellerian Hormone (AMH), compared to women without BRCAm (wild-type). MATERIAL AND METHODS: Systematic searches of PubMed, Medline, Scopus, Embase,...

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Identifiers

PMID: 34627117
DOI: 10.1016/j.breast.2021.09.006
PMCID: PMC8501498

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