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Article

BRCA1 germline mutations may be associated with reduced ovarian reserve.

Fertility and sterility - 1 Dec 2014

Wang Erica T, Pisarska Margareta D, Bresee Catherine, Chen Yii-Der Ida, Lester Jenny, Afshar Yalda, Alexander Carolyn, Karlan Beth Y

Abstract excerpt

OBJECTIVE: To determine whether BRCA carriers have a decreased ovarian reserve compared with women without BRCA mutations, because BRCA mutations may lead to accelerated oocyte apoptosis due to accumulation of damaged DNA. DESIGN: Cross-sectional study. SETTING: Academic tertiary care center. PATIENT(S): A total of 143 women, aged 18-45 years, who underwent clinical genetic testing for BRCA deleterious mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25256924
DOI: 10.1016/j.fertnstert.2014.08.014
PMCID: PMC4372188

Genes

AMH
BRCA1
BRCA2

Provenance

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