Article

Association of Germline BRCA Pathogenic Variants with Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data

2021-02-16

Abstract excerpt

<h4>Purpose</h4> To determine whether germline BRCA pathogenic variants (g BRCA ) are associated with decreased ovarian reserve. <h4>Materials and Methods</h4> An individual patient-data meta-analysis was performed using 5 datasets on 828 evaluable women who were tested for g BRCA . Of those, 250 carried g BRCA while 578 had tested negative and served as controls. Of the women with g BRCA , four centers studied th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ec45dbf-110d-5509-808b-ff6172689003
DOI: 10.1101/2021.02.13.21251672

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association of Germline BRCA Pathogenic Variants with Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level DataDOI 10.1101/2021.02.13.21251672Read

Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis.Semantic proximity Read

Reduced reproductive potential in young healthy women with hereditary breast and/or ovarian cancer syndromeSemantic proximity Read

BRCA1 germline mutations may be associated with reduced ovarian reserve.Semantic proximity Read

Anti-Müllerian hormone serum concentrations of women with germline<i>BRCA1</i>or<i>BRCA2</i>mutationsSemantic proximity Read

Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: Results from EMBRACESemantic proximity Read

Serum AMH levels in healthy women fromBRCA1/2mutated families: are they reduced?Semantic proximity Read

BRCA1/2 genes mutations, ovarian reserve and female reproductive outcomes: a systematic review of the literature.Semantic proximity Read

Ovarian cancer risk of Chinese women with BRCA1/2 germline pathogenic variantsSemantic proximity Read

Pathogenic germline variants among patients with ovarian cancer by self-reported ancestry: A commercial laboratory collaborative research registry study.Semantic proximity Read

Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1).Semantic proximity Read

The Impact of BRCA1- and BRCA2 Mutations on Ovarian Reserve Status.Semantic proximity Read

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in womenSemantic proximity Read