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Article

Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2010

Oktay Kutluk, Kim Ja Yeon, Barad David, Babayev Samir N

Abstract excerpt

PURPOSE: Germline mutations in BRCA genes are associated with breast and ovarian cancer susceptibility. Because infertility is associated with breast and ovarian cancer risks, we hypothesized that the mutations in the BRCA gene may be associated with low response to fertility treatments. METHODS: We performed ovarian stimulation in 126 women with breast cancer by using letrozole and gonadotropins for the purpose...

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Identifiers

PMID: 19996028
DOI: 10.1200/JCO.2009.24.2057
PMCID: PMC3040011

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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