Regularized sequence-context mutational trees capture variation in mutation rates across the human genome.

Abstract excerpt

Germline mutation is the mechanism by which genetic variation in a population is created. Inferences derived from mutation rate models are fundamental to many population genetics methods. Previous models have demonstrated that nucleotides flanking polymorphic sites-the local sequence context-explain variation in the probability that a site is polymorphic. However, limitations to these models exist as the size of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bayes Theorem
• Share to Genome, Human