Article

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The nervous system relies on billions of neurons connected through trillions of synapses to support a vast array of vital functions. Despite the critical importance of this synaptic network, the cellular mechanisms dictating synapse formation during human neurodevelopment remain unclear. Long-distance trafficking of synaptic components is critical for both synaptogenesis and the maintenance of s...

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Literature Corpus work: 2d84fd5a-036f-502c-92b5-d4913e5bfea5
DOI: 10.64898/2026.01.14.699478

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