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Article

Microtubule-microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in Drosophila oocytes.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Lu Wen, Winding Michael, Lakonishok Margot, Wildonger Jill, Gelfand Vladimir I

Abstract excerpt

Cytoplasmic streaming in Drosophila oocytes is a microtubule-based bulk cytoplasmic movement. Streaming efficiently circulates and localizes mRNAs and proteins deposited by the nurse cells across the oocyte. This movement is driven by kinesin-1, a major microtubule motor. Recently, we have shown that kinesin-1 heavy chain (KHC) can transport one microtubule on another microtubule, thus driving...

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Identifiers

PMID: 27512034
DOI: 10.1073/pnas.1522424113
PMCID: PMC5003289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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