Article
Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.
Genome medicine - 9 Aug 2016
Halliwill Kyle D, Quigley David A, Kang Hio Chung, Del Rosario Reyno, Ginzinger David, Balmain Allan
Abstract excerpt
BACKGROUND: Body mass index (BMI) has been implicated as a primary factor influencing cancer development. However, understanding the relationship between these two complex traits has been confounded by both environmental and genetic heterogeneity. METHODS: In order to gain insight into the genetic factors linking BMI and cancer, we performed chemical carcinogenesis on a genetically heterogeneous cohort of...
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