Article
Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2008
Gordon Ryan R, Hunter Kent W, La Merrill Michele, Sørensen Peter, Threadgill David W, Pomp Daniel
Abstract excerpt
High dietary fat intake and obesity may increase the risk of susceptibility to certain forms of cancer. To study the interactions of dietary fat, obesity, and metastatic mammary cancer, we created a population of F(2) mice cosegregating obesity QTL and the MMTV-PyMT transgene. We fed the F(2) mice either a very high-fat or a matched-control-fat diet, and we measured growth, body composition, age at mammary tumor...
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